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wild type b6 mice  (Jackson Laboratory)

 
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    Jackson Laboratory wild type b6 mice
    Wild Type B6 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Serum chemistries and blood counts of LNP-injected piglets (A) LNP-mRNA delivery study design schematic. Three 20-day-old SRM-1 piglets were injected with 0.4 mg kg −1 of LNP-mRNA carrying Cre and tissues were harvested after 14 days (B) LNP formulation schematic of mRNA using microfluidic mixing. (C) Absolute values of serum ALT, AST, creatinine, creatinine kinase, and albumin as well as blood cell counts (white blood cells, lymphocytes, neutrophils, red blood cells) in three LNP-injected SRM-1 pigs (purple), one mock-injected SRM-1 pig (gray), and 2 non-injected <t>wild</t> <t>type</t> sibling piglets (black). The red dashed lines are the high and low references ranges supplied by the diagnostic laboratory. One blood sample per piglet was taken at each time point.
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    Serum chemistries and blood counts of LNP-injected piglets (A) LNP-mRNA delivery study design schematic. Three 20-day-old SRM-1 piglets were injected with 0.4 mg kg −1 of LNP-mRNA carrying Cre and tissues were harvested after 14 days (B) LNP formulation schematic of mRNA using microfluidic mixing. (C) Absolute values of serum ALT, AST, creatinine, creatinine kinase, and albumin as well as blood cell counts (white blood cells, lymphocytes, neutrophils, red blood cells) in three LNP-injected SRM-1 pigs (purple), one mock-injected SRM-1 pig (gray), and 2 non-injected <t>wild</t> <t>type</t> sibling piglets (black). The red dashed lines are the high and low references ranges supplied by the diagnostic laboratory. One blood sample per piglet was taken at each time point.
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    Image Search Results


    Serum chemistries and blood counts of LNP-injected piglets (A) LNP-mRNA delivery study design schematic. Three 20-day-old SRM-1 piglets were injected with 0.4 mg kg −1 of LNP-mRNA carrying Cre and tissues were harvested after 14 days (B) LNP formulation schematic of mRNA using microfluidic mixing. (C) Absolute values of serum ALT, AST, creatinine, creatinine kinase, and albumin as well as blood cell counts (white blood cells, lymphocytes, neutrophils, red blood cells) in three LNP-injected SRM-1 pigs (purple), one mock-injected SRM-1 pig (gray), and 2 non-injected wild type sibling piglets (black). The red dashed lines are the high and low references ranges supplied by the diagnostic laboratory. One blood sample per piglet was taken at each time point.

    Journal: Molecular Therapy Advances

    Article Title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors

    doi: 10.1016/j.omta.2026.201729

    Figure Lengend Snippet: Serum chemistries and blood counts of LNP-injected piglets (A) LNP-mRNA delivery study design schematic. Three 20-day-old SRM-1 piglets were injected with 0.4 mg kg −1 of LNP-mRNA carrying Cre and tissues were harvested after 14 days (B) LNP formulation schematic of mRNA using microfluidic mixing. (C) Absolute values of serum ALT, AST, creatinine, creatinine kinase, and albumin as well as blood cell counts (white blood cells, lymphocytes, neutrophils, red blood cells) in three LNP-injected SRM-1 pigs (purple), one mock-injected SRM-1 pig (gray), and 2 non-injected wild type sibling piglets (black). The red dashed lines are the high and low references ranges supplied by the diagnostic laboratory. One blood sample per piglet was taken at each time point.

    Article Snippet: To determine the in vivo stability and delivery efficiency of LNPs with the same formulation used for the systemic pig study, wild-type BALB/cJ mice (male and female, Jackson Laboratory, stock #000651), aged 10–16 weeks and weighing 18–25 g were used for firefly luciferase mRNA delivery experiments.

    Techniques: Injection, Formulation, Diagnostic Assay